UnknownNot Applicable

Challenge Test for Acetylsalicylic Acid Hypersensitivity

Norway50 participantsStarted 2012-09

Plain-language summary

The investigators want to find new challenge test for Acetylsalicylic hypersensitivity / Aspirin hypersensitivity. The investigators suggest that this new test will be as efficient as the already established protocols in terms of sensitivity and specificity.

Who can participate

Age range18 Years – 60 Years

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Persons between 18 and 60 years of age * Suspected Acetylsalicylic Acid Hypersensitivity Exclusion Criteria: * History on anaphylactic shock after NSAIDS intake * History on gastric ulcer after NSAIDS intake * Patients previously gone through testing or desensitisation for Aspirin hypersensitivity * Clinical unstable asthma or baseline FEV1\<70% * Severe disease of the heart, digestive tract, liver or kidney * Severe chronic urticaria * Present conjunctivitis * Pregnancy

What they're measuring

Inspiratory nasal flow measured by Rhinomanometry

Timeframe: Within 45 min from challenge

Expiratory nasal flow measured by Rhinomanometry

Timeframe: Within 45 min from challenge

Pulmonary forced expiratory volume in 1 second (FEV1)

Timeframe: Within 45 min from challenge

Trial details

NCT IDNCT01681615

SponsorHelse Stavanger HF

Sponsor typeOTHER_GOV

Study typeINTERVENTIONAL

Primary completion2013-03

Contact for this trial

Gregor Bachmann-Harlidstad, MD, PhD

0047 02900 (central) Gregor.Bachmann-Harlidstad2@ahus.no

View on ClinicalTrials.gov More Asthma Aspirin-sensitive trials