CompletedNot Applicable

Comparison of Laminaria and Misoprostol for Cervical Preparation Before Second Trimester Surgical Abortion

Israel84 participantsStarted 2007-11

Plain-language summary

This study compares the effectiveness of cervical preparation before second trimester abortion using laminaria versus vaginal Misoprostol. The investigators hypothesize that medical preparation of the cervix with vaginal Misoprostol is superior to mechanical preparation using laminaria. The investigators believe that medical preparation makes the procedure easier to perform, equally safe, without addition of pain or discomfort.

Who can participate

Age range

15 Years – 45 Years

Sex

FEMALE

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Pregnant patients with a viable singleton * Pregnancy 14-20 weeks of gestation * Admitted for termination of pregnancy Exclusion Criteria: * Contraindication for administration of Misoprostol * Patients with more than one previous cesarean section scar * Patients with impaired coagulation * Significant pulmonary or cardiac disease * Non viable pregnancy * Placenta accreta or previa by ultrasound

Questions worth asking your doctor

Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.

1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?

Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.

Questions for the trial coordinator

The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.

1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?

A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.

What they're measuring

Initial cervical opening and the need for further dilatation at the start of the procedure

Timeframe: 8-12 hours after insersion of laminaria or Misoprostol

Trial details

NCT IDNCT01678703

SponsorWolfson Medical Center

Sponsor typeOTHER_GOV

Study typeINTERVENTIONAL

Primary completion2010-06

View on ClinicalTrials.gov More Induced; Abortion, Nonmedical trials