CompletedNot Applicable

The COX-2 Gene and the Immune System

United States117 participantsStarted 2013-05-02

Plain-language summary

Background: \- The immune system contains several different types of cells in the blood and other parts of the body. The body can fight infections well with the right balance of these cell types. The wrong balance of cell types may cause diseases, such as allergies or asthma. The COX-2 gene may help decide the balance of cell types that the body makes as part of the immune system. It may also play a role in certain immune system diseases. Researchers want to see how COX-2 affects the cells in the immune system. Objectives: \- To study how the COX-2 gene works in the body s immune system. Eligibility: \- Individuals 18 years of age and above who are part of the Environmental Polymorphisms Registry. Design: * Participants will have one study visit at the National Institutes of Health. They will collect a urine sample at home on the morning of the study visit. * Participants will have a physical exam and medical history. They will provide a blood sample. They will also give researchers the urine sample they collected that morning. * No treatment will be provided as part of this study.

Who can participate

Age range18 Years – 150 Years

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

* INCLUSION CRITERIA: * Participant of the Environmental Polymorphisms Registry and current contact information available * Genotype information available for relevant 765G\>C and 8473T\>C COX2 polymorphisms, which indicates: * Individuals who are WT with respect to both 765G\>C and 8473T\>C (N=31) * Individuals who are WT with respect to 765G\>C and homozygous for 8473T\>C (N=31) * Individuals who are homozygous for both 765G\>C and 8473T\>C (N=31) * Age 18- 65 years * Race self-identified as White or Black and Non-Hispanic ethnicity * Willing and able to provide informed consent * Able to comply with all protocol procedures EXCLUSION CRITERIA: * History of infection within the preceding 1 week or an oral temperature \>38 degrees C * Current daily or chronic use of corticosteroids (systemic, inhaled and topical). * Any current conditions known to impact peripheral white blood cell count (e.g., leukemia, lymphopenia, AIDS, other immunodeficiency disorders) * Current daily or chronic use of systemic immunosuppressants. * Current pregnancy or lactation * Unwilling or unable to: * Fast (including alcohol and caffeine-containing products) and discontinue tobacco use for 12 hours prior to the study visit * Withhold all prescribed and over-the-counter medications and supplements the morning of the study visit, until after the visit is completed * Refrain from taking the following medications and supplements for 7 days prior to the study visit: * NSAIDs * Co…

What they're measuring

To determine whether 765>C is associated with altered Th2, Th9, and Th17 differentiation in vivo

Timeframe: Ongoing

To determine whether 8473T>C is associated with altered Th2, Th9, and Th17 differentiation in vivo

Timeframe: Ongoing

Trial details

NCT IDNCT01678222

SponsorNational Institute of Environmental Health Sciences (NIEHS)

Sponsor typeNIH

Study typeOBSERVATIONAL