TerminatedNot Applicable

Hypothalamic-pituitary Effects After Endoscopic Third Ventriculostomy

Stopped: Recruitment failure

France11 participantsStarted 2012-07

Plain-language summary

Background: Endoscopic third ventriculostomy (ETV) is a standard procedure for the treatment of obstructive hydrocephalus in children and adults. Perforation of the third ventricle floor which is part of the hypothalamic-pituitary neuronal network is the key of this surgical procedure. Purpose: There are no prospective data available about the endocrine effects after ETV in children and adults. The principal aim of this prospective study is to evaluate the variability of hypothalamic-pituitary hormones and clinical effects in children and adults after ETV in order to plan a multicentric study.

Who can participate

Age range6 Months

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * all patients over 6 months old with obstructive hydrocephalus who are referred for planned endoscopic third ventriculocisternostomy Exclusion Criteria: * MRI contraindication, non obstructive hydrocephalus, life expectancy inferior of 3 months, ETV in emergency, hydrocephalus aetiology interaction with hypothalamic-pituitary hormones, hydrocephalus already treated, basilar artery malformations, to be allergic to tetracosactide (synacthene) and to benserazide (Levodopa).

What they're measuring

Variability of hypothalamic-pituitary hormones after endoscopic third ventriculostomy

Timeframe: 12 months

Trial details

NCT IDNCT01675037

SponsorUniversity Hospital, Toulouse

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2015-07

View on ClinicalTrials.gov More Obstructive Hydrocephalus trials