CompletedNot Applicable

Metabolic Imaging in Carotid Atherosclerosis

United Kingdom26 participantsStarted 2012-10-10

Plain-language summary

Hardening of the arteries (atherosclerosis) is a common disorder that causes heart attacks and strokes. PET CT and contrast-enhanced MRI scans are two new ways of assessing atherosclerosis. The investigators propose to perform PET CT and MRI scans on patients with hardening of the neck arteries due to undergo surgery to remove the hardened areas. The investigators will then be able to compare the hot spots found on these scans with what the investigators can see in the removed specimens under the microscope in the laboratory. This will give investigators insight into the value of PET CT and MRI as tools for assessing atherosclerosis. It will also provide the investigators with new information relating to the underlying processes that give rise to atherosclerosis and will pave the way for the future development of new treatments.

Who can participate

Age range18 Years

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Patients with carotid stenosis due to undergo carotid endarterectomy. Exclusion Criteria: * Patients with new stroke and a modified Rankin score \>3 * Chronic Kidney Disease with eGFR of \<30 mL/min/1.73m2 * Pregnant women * Poorly controlled diabetes mellitus (HbA1c \> 8.5%) or diabetes mellitus requiring insulin * Prior ipsilateral carotid intervention * Prior neck irradiation * Inability to tolerate the supine position * Participation in the study would result in delay to surgery * Psychiatric illness/social situations that would limit compliance with study requirements * Specific contraindications to MRI (e.g. pacemaker) * History of allergic reaction attributed to ferumoxytol or similar * Known or suspected iron overload (genetic haemochromatosis or history of multiple transfusions) * History of allergic reaction attributed to 18F-FDG or 18F-NaF or similar * History of allergic reaction to iodine or iodine-based contrast media

What they're measuring

The Standardized Uptake Value (SUV) for 18F-Fluoride of the ipsilateral carotid artery

Timeframe: 1-2 days after PET/CT scan

Trial details

NCT IDNCT01674257

SponsorUniversity of Edinburgh

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2014-06-30