Defining Late Onset Occult Asymptomatic Cardiotoxicity in Childhood Cancer Survivors Exposed to Anthracycline Therapy

5.1 A. Subject Inclusion Criteria * Childhood cancer survivors from the late effect clinic who had received ≥240 mg/m2 anthracyclines, been in complete remission and off chemotherapy for a minimum of 2 years. * Age \> 9 years of age\* * Parental/caregiver consent and subject assent to enrollment \* Age \> 9 years of age was chosen to avoid the need for general anesthesia or sedation B. Subject Inclusion Criteria * Enrolled in part A of the study, which took place from October 2011 to July 2013. * Parental/caregiver consent and subject assent to enrollment C. Subject Inclusion Criteria * Childhood cancer survivors from the late effect clinic who had received \< 300 mg/m2 anthracyclines, been in complete remission and off chemotherapy for a minimum of 1 year * Age ≥ 9 years of age\* * Parental/caregiver consent and subject assent to enrollment * \* Age \> 9 years of age was chosen to avoid the need for general anesthesia or sedation 5.2 A. Subject Exclusion Criteria * Contraindications to CMRI.\* * Pregnancy\*\* \* Contraindications to CMRI (i.e., magnetically activated implants/devices; cardiac pacemaker or wires; after the patients are scheduled for CMRI, they will be sent our standard pre-MRI paperwork/questionnaire, to determine eligibility to have an MRI) \*\*If a female patient of child bearing age is not sure if they are pregnant or not, as part of the standard CMRI with contrast procedures, a urine pregnancy test will be done. If the result is positive the s…