UnknownNot Applicable

Preconceptional Thromboprophylaxis in Recurrent PREGNANCY LOSSES Caused by Antiphospholipid Syndrome

Egypt316 participantsStarted 2012-03

Plain-language summary

Preconceptional use of low molecular weight heparin (enoxaparin) and aspirin in patient with recurrent miscarriages with positive anti phospholipid antibodies increase the implantation rate and the duration of pregnancy with low complications to the mother and the baby.

Who can participate

Age range18 Years – 40 Years

SexFEMALE

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Inclusion criteria

✓. All women with recurrent first-trimester miscarriage and all women with one or more second-trimester miscarriage who screened before pregnancy for antiphospholipid antibodies.
✓. To diagnose antiphospholipid syndrome it is mandatory that the woman has two positive tests at least 12 weeks apart for either lupus anticoagulant or anticardiolipin antibodies of immunoglobulin G and/or immunoglobulin M class present in a medium or high titre over 40 g/l or ml/l,or above the 99th percentile).

Exclusion criteria

✕. Age above forty years old .
✕. Intrauterine abnormalities (as assessed by ultrasound, hysterosonography, hysterosalpingogram, or hysteroscopy).
✕. Fibroids distorting uterine cavity .
✕. Abnormal parental karyotype .
✕. Other identifiable causes of recurrent miscarriages (tests initiated only if clinically indicated) e.g., diabetes, thyroid disease and systemic lupus erythematosus (SLE).

What they're measuring

Pregnancy continuation beyond twelve weeks gestation

Timeframe: ONE YEAR

Trial details

NCT IDNCT01661439

SponsorWoman's Health University Hospital, Egypt

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2014-06

Contact for this trial

Alaa Mahmoud Ismail, M.D

+201000459514 dr.alaa_ismail@yahoo.com

View on ClinicalTrials.gov More Recurrent Pregnancy Losses trials