Procalcitonin-guided Detection of Streptococcal Acute Tonsillitis
Denmark200 participantsStarted 2012-08
Plain-language summary
The primary purpose of the present study is to investigate the usefulness of Procalcitonin as a supplement to the Streptococcal antigen test and Centor criteria in the differential diagnose making between Streptococcal and non-Streptococcal acute tonsillitis.
Furthermore, the investigators aim to examine Procalcitonin as a diagnostic marker in acute tonsillitis due to Fusobacterium Necrophorum.
Who can participate
Age range
15 Years – 40 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Patients with acute tonsillitis:
Inclusion Criteria:
* Age between 15 and 40 years.
* Subjective and objective signs of Acute Tonsillitis + presents of 2-4 Centor Criteria.
* participation accept after verbal and written information.
Exclusion Criteria:
* Antibiotic treatment within the last month.
* Other infection within the last month.
* Inadequate tonsil swabs due to lack of cooperation.
* Suspicion of peritonsillar abscess
Control patients:
Inclusion criteria:
* Age between 15 and 40 years.
* Participation accept after verbal and written information.
Exclusion Criteria:
* Antibiotic treatment within the last month.
* Infection within the last month.
* Tonsillectomy
* More than 2 cases of acute tonsillitis within the last 12 months.
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Procalcitonin
Timeframe: The participants will bee examined in family practice in 30 minuts, measurement results will be available after 3-4 month (average)