Effects of Adaptive Servoventilation in Patients With Systolic Heart Failure and Sleep-Disordered Breathing

Inclusion Criteria: * Stable heart failure NYHA ≥ II * EF ≤ 45% * without sleep-disordered breathing (apnea-hypopnea-index \<5/h) and those with moderate to severe central sleep apnea (apnea-hypopnea index ≥ 15/h) with or without adaptive servoventilation therapy Exclusion Criteria: * Cardiac resynchronization or pacemaker implantation within the last 6 months * Significant COPD with an forced expiratory one-second capacity relative to vital capacity (FEV1/VC)\< 70% (GOLD III) * Respiratory insufficiency requiring long-term oxygen therapy * Daytime hypercapnia at rest (pCO2 \> 45 mmHg) * Current ventilation therapy * Cardiac surgery, PCI, myocardial infarction, unstable angina, TIA or stroke within 12 weeks prior to randomization * Acute myocarditis within 6 months prior to randomization * Pregnancy