Impact of Early Goal-directed Fluid Therapy in Septic Patients Undergoing Emergency Surgery

Inclusion Criteria: * Adults \> 18 years * Severe sepsis\* as defined by the ACCCP/SCCM consensus conference * Need for emergent interventional procedure under general anesthesia with an expected duration \> 120 min (in and out patients). Exclusion Criteria: * Patients responding to early fluid resuscitation (20ml/kg) who don't require a CVC * Neurotrauma (Glasgow Coma Score \< 12) and/ or medullar trauma * Known pregnancy or diagnosed by US or Ct-scan (\> 14 weeks) * Sustained cardiac arrhythmia (see Logbook P8) * Known or diagnosed severe cardiac valvular dysfunction (stenosis, insufficiency) (see Logbook P8) * Known or diagnosed intracardiac shunt: interventricular or atrial defect (see Logbook P8) * Burn injury \> 10% * Needed emergency thoracotomy or ABC resuscitation protocol * Pre-existing severe liver dysfunction(Child-Pugh class C) * Do-not-resuscitate order, died within 48h of admission