CompletedPhase 1

Transcranial Magnetic Stimulation in Children With Stroke

United States4 participantsStarted 2012-05

Plain-language summary

This is a pilot study of repetitive transcranial magnetic stimulation (rTMS) to test tolerance and efficacy in children who have hemiparesis from acquired or presumed perinatal stroke.

Who can participate

Age range6 Years – 18 Years

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion criteria

✓. A history of ischemic or hemorrhagic stroke at least 6 months prior to recruitment, and causing current unilateral motor impairment of hand function (scoring 1-3 on a modified Ashworth scale; scale explained in Appendix).
✓. Cerebral infarction spares the transcallosal pathways.
✓. Cerebral injury confirmed by brain MRI or CT
✓. Ages 6-18 years inclusive.

Exclusion criteria

✕. The presence of an implanted device such as a pacemaker, vagal nerve stimulator, or recently implanted cardiovascular stent; arterial aneurysms; arteriovenous malformations; obstructive hydrocephalus.
✕. Infarction of the cortical motor areas.
✕. Presence of a brain tumor or suspected neurodegenerative disease.
✕. Intractable epilepsy or a history of poorly controlled epilepsy.
✕. Current use of medications that may lower seizure threshold (such as specific antipsychotics, specific antidepressants, amphetamines)
✕. Hand function limited to rigid flexion or extension (score = 4 on the modified Ashworth scale)
✕. Disorders causing hallucinations, delusions, or excessive anxiety or depression.
✕. Pre-existing chronic pain syndromes including intractable headache and chronic daily headache.

What they're measuring

Tolerance to repetitive stimulation

Timeframe: Up to 2 days

Trial details

NCT IDNCT01637129

SponsorNationwide Children's Hospital

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2013-08

View on ClinicalTrials.gov More Hemiparesis trials