Effects of Tocotrienols Supplementation on Platelet Aggregation in Subjects With Metabolic Syndrome

Inclusion Criteria: * Age 25-60 year * Haemoglobin level \>11.5 g/dL in women and \>12.5 g/dL in men * Serum ferritin \> 15µg/L * According to Clinical Practice Guidelines, Management of Type 2 Diabetes Mellitus in Malaysia (2009), metabolic syndrome subjects are identified with: * Waist circumference ≥ 90 cm in men and ≥ 80 cm in women and with any two of the following criteria: * Elevated triacylglycerols \> 1.7 mmol/L * Low HDL cholesterol \< 1.0 mmol/L in men and \< 1.3 mmol/L in women * Elevated blood pressure ≥ 130/≥85 mm Hg * Fasting glucose ≥ 5.6 mmol/L to 7 mmol/L Exclusion Criteria: * Medical history of myocardial infarction, angina, ischemic attack, hemorrhagic stroke, deep vein thrombosis, coronary artery disease, bleeding disorder, cancer, allergy to vitamin E * Smoker * Lactose intolerance * Pregnancy or lactation * Current use of vitamin E, medications modulating blood coagulation, hypertension, lipid-lowering and glucose-lowering agents, corticosteroids * Significant hepatic and renal impairment * Fever, cold or infection during bleeding day * Alcoholic