NUtriGenomic Analysis in Twins (NCT01631123) | Clinical Trial Compass
CompletedNot Applicable
NUtriGenomic Analysis in Twins
Germany120 participantsStarted 2009-09
Plain-language summary
This is an intervention study in healthy adult twins with the aim to investigate the genetic determination of metabolic responses towards an isocaloric high carbohydrate, low fat diet versus an isocaloric low carbohydrate, high fat diet.
Who can participate
Age range18 Years – 70 Years
SexALL
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Inclusion Criteria:
* Healthy twins
* BMI 18,5-35kg/m²
* BMI difference \< 3kg/m² within the pair of twins
* Stable weight during the last 3 months
* Willingness to comply with the assigned diets over the study period
Exclusion Criteria:
* Consumptive diseases
* Intake of metabolic influence a/o anticoagulent drugs (e.g. cortisone, ASS, antibiotics)
* Diabetes type 1 and type 2
* Pregnancy
* Chronic disease of heart, kidney, liver
* High grade anaemia
* High grade infection disease
* Relevant change of body weight(+/- 2kg)during isoenergetic 12-weeks of dietary intervention
* Missing data about primary outcome measures (IVGTT, MTT, data about dietary intake from food diaries or food protocols)
* Significant deviation from dietary targets during the monitored 12 weeks isoenergetic period
* Allergies including food allergies
What they're measuring
1
Genetic variance of change in insulin secretion and sensitivity after sequential diets