The investigators propose to obtain facial photographs for use in testing a computer algorithm that recognizes males at high risk for Hypohidrotic Ectodermal Dysplasia (XLHED). FDNA (www.fdna.com), a software company with expertise in the area of facial recognition, is collaborating with the Sponsor in algorithm development based on 2D photographs not requiring special photographic technologies. A frontal facial photograph will be taken at the time of study conduct. The anonymized photographs will be transmitted to FDNA for analysis. A limited number of unaffected controls will be also be recruited. A subset of affected males between ages 5 and 25 years will have the option of having a blood draw for a set of laboratory studies assessing nutritional status.
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Exploratory Objective - To collect demographic and clinical status information in male subjects affected by HED using a medical questionnaire
Timeframe: Study day 1 - Day of study conduct
Exploratory Objective - To test and refine a computer algorithm for facial recognition of XLHED based on 2D facial photographs
Timeframe: Study day 1 - Day of study conduct
Exploratory Objective - To identify nutritional patterns associated with XLHED
Timeframe: Study day 1 - Day of study conduct
Exploratory Objective - To test for the presence of genetic mutations in a subset of HED-affected subjects enrolled in this study who lack prior genetic diagnosis
Timeframe: Study day 1 - Day of study conduct