Pharmacokinetic Study of Ceftaroline Fosamil/Avibactam in Adults With Augmented Renal Clearance

Inclusion Criteria: * Male or female adults ≥ 18 and ≤ 55 years old * Augmented renal clearance, defined as: * Estimated CrCl ≥ 115 mL/min (calculated using modified Cockcroft-Gault, before the measured 8-hour urine collection) * Measured CrCl ≥ 140 mL/min (from an 8-hour urine collection) * Hospitalized and diagnosed with SIRS, defined by at least 2 of the following: * Temperature (oral, rectal, tympanic, or core) \> 38.5°C or \< 35.0°C * Heart rate \> 90 beats/min * Respiratory rate \> 20 breaths/min or PaCO2 \< 32 mmHg * Leukocytosis (\> 12,000 white blood cells \[WBC\]/mm3), leukopenia (\< 4000 WBC/mm3), or bandemia (\> 10% immature neutrophils \[bands\] regardless of total peripheral WBC) * Requires indwelling urinary bladder catheter per standard of care (through the end of the 8-hour urine collection) Exclusion Criteria: * History of any known hypersensitivity or allergic reaction to cephalosporins or any β-lactam antimicrobial (eg, penicillins) * History of chronic kidney disease, hemodialysis, or peritoneal dialysis; or history of acute renal replacement therapy (eg, hemodialysis, hemofiltration) associated with current illness * Suspected rhabdomyolysis or creatine kinase \> 10,000 U/L * Significant anemia defined as hemoglobin \< 9 g/dL or hematocrit \< 27% * Transfusion of packed red blood cells (PRBC) or whole blood within 24 hours of study drug infusion or anticipated need for a transfusion before the last PK blood sample is collected * If femal…