CompletedNot Applicable

Amyloid Imaging and Cognitive Impairment After Intracerebral Hemorrhage

France70 participantsStarted 2012-01

Plain-language summary

To evaluate Pet AV-45 Amyloid imaging in the etiological diagnosis of primary non traumatic intracerebral hemorrhage (Cerebral Amyloid Angiopathy and hypertension related hemorrhage).We hypothesize that patients with lobar hemorrhage (probably related to Cerebral Amyloid Angiopathy) will have a greater AV45 cortical binding than patients with deep hemorrhage (probably related to hypertension).

Who can participate

Age range40 Years – 90 Years

SexALL

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Inclusion Criteria: * Age : 40-90 years, * Non traumatic primary intracerebral hemorrhage during acute phase (less than 30 days from hemorrhage onset) confirmed on brain imaging (CT and/or MRI). * Correct visual, hearing and language functions to perform neuropsychological tests. * Written consent of patient Exclusion Criteria: * Secondary causes of intracerebral hemorrhage : vascular malformations (Arteriovenous malformation, intracranial aneurysm, Cavernous angioma, dural arteriovenous fistula), cerebral venous thrombosis, intracranial neoplasm, coagulopathy, vascularitis, Cocaine or alcohol use, Hemorrhagic ischemic stroke. * Pregnancy * Contraindication to MRI * progressive neoplasm * Cognitive impairment secondary to progressive neurological disease * Depression, * Drug addiction

What they're measuring

Pet-AV45 cortical binding

Timeframe: Acute phase of intracerebral hemorrhage ie during the first month after hemorrhage onset.

Trial details

NCT IDNCT01619709

SponsorUniversity Hospital, Toulouse

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2017-06

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