TerminatedPhase 4

Delayed Start to Ovarian Stimulation

Stopped: Slow enrollment resulted in withdraw of funding

United States30 participantsStarted 2012-05

Plain-language summary

In couples with infertility secondary to Diminished Ovarian Reserve, the investigators hypothesize that a delayed start (7 day) to ovarian stimulation with an GnRH antagonist (Ganirelix) will improve oocyte maturation and quality, and improve pregnancy outcomes.

Who can participate

Age range18 Years

SexFEMALE

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Antral Follicle Count (AFC) less than or equal to 4 as measured by transvaginal ultrasound (TVUS), or * Cancellation of a prior IVF cycle due to poor ovarian response. * Patients will receive an antagonist stimulation protocol for IVF, or IVF with Intracytoplasmic Sperm Injection (ICSI). Exclusion Criteria: * Severe male factor infertility requiring surgical intervention to obtain sperm * Major uterine abnormality, * Preimplantation genetic diagnostic (PGD) testing, * Planned cycles without embryo transfer (for example, freeze-all, donor, or surrogate cycles).

What they're measuring

Fertilization Proportions

Timeframe: 8 to 24 hours after in vitro fertilization, oocytes will be checked for fertilization

Number of Oocytes Retrieved

Timeframe: up to 1 hour after oocytes retrieved

Trial details

NCT IDNCT01614067

SponsorUniversity of California, San Francisco

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2014-07

Results submitted2021-05-20

View on ClinicalTrials.gov More Diminished Ovarian Reserve trials