A Dose Escalation Study Using Collagenase Clostridium Histolyticum in the Treatment of Lipoma

Inclusion Criteria: * Clinical history lipoma at least one year and no treatment within last 90 days * Lipoma diagnosed as benign * Lipoma is a single mass with easily definable edges * Lipoma has an area of 2.0 to 17 cm squared * Women of childbearing potential must use an acceptable method of birth control Exclusion Criteria: * Lipomas on the head, neck, hand or foot, or female breast * Women who are nursing or pregnant * Subjects who have participated in any investigational drug trial within 45 days of enrollment in this study * Subjects with known allergy to collagenase or any of the inactive ingredients in XIAFLEX * Subjects with diabetes or any medical condition that would make the subject unsuitable for enrollment. * Subjects having a history of trauma in the area of the lipoma * Subjects with a history of connective tissue diseases or rheumatological diseases. * Subjects with uncontrolled hypertension * Subjects currently receiving or planning to receive anticoagulant medication except for less than 150 mg aspirin daily and over-the-counter nonsteroidal anti-inflammatory drugs) within 7 days before injection of study drug * Subjects having the following laboratory abnormalities: * ALT/AST greater than 3 times the upper limit of normal * Creatinine greater than 2 * Hemoglobin/hematocrit and WBC outside the normal range