RecruitingPhase 1/2

Multimodal Imaging Assessment of the Inflammatory Atheromatous Plaque

Switzerland20 participantsStarted 2012-04

Plain-language summary

The present study aims at assessing the ability of 68Ga-NODAGA-RGD PET/CT for the detection of inflammatory atheromatous plaques in the carotid arteries, compared to 18F-FDG PET/CT, MRI and US and to determine the contribution of each imaging technique. Current gold standard for inflammation is histopathology. Hypothesis : 68Ga-NODAGA-RGD might give a better initial evaluation of patients with atheromatous plaques in the carotid artery eligible for endarterectomy.

Who can participate

Age range18 Years – 85 Years

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * age \<= 85 years * Karnofsky \>= 80% * patient with indication ofr carotid endarterectomy * signed consent form Exclusion Criteria: * indication for surgery other than endarterectomy \<14 days * contraindication to surgery * contraindication to MRI * contraindication to gadolinium injection (stage 4/5 kidney insufficiency, GFR\<30ml/min/1.73m2) * pregnancy, breastfeeding * lack of discernment

What they're measuring

Comparison of each method of imaging for the detection of inflammatory atheromatous plaques

Timeframe: Within1 month of endarterectomy

Trial details

NCT IDNCT01608516

SponsorUniversity of Lausanne Hospitals

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2024-12

Contact for this trial

John O. Prior, PhD, MD

+41 21 314 43 48 john.prior@chuv.ch

View on ClinicalTrials.gov More Inflammation trials