Description of Abdominal and Gluteo-femoral Subcutaneous Adipose Tissue Cell Population in Women … (NCT01605578) | Clinical Trial Compass
CompletedNot Applicable
Description of Abdominal and Gluteo-femoral Subcutaneous Adipose Tissue Cell Population in Women - GLUTAB
France20 participantsStarted 2012-05-14
Plain-language summary
The purpose of this study is to compare, in healthy women, the adipose tissue composition between abdomen and thigh and then determine whether differences exist independently of the state of obesity.
The findings of this study may help to explain the mechanism contributing to a beneficial role of gluteo-femoral fat contrasting with a deleterious role of abdominal fat on cardiovascular and metabolic dysfunctions.
Who can participate
Age range25 Years – 45 Years
SexFEMALE
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Inclusion Criteria:
* women between 15 and 45 years old
* with genital activity
* stable weight during the previous 3 months
* BMI from 20 to 28
* regular menstrual cycles (28 +/- 2 days) during the previous 3 months
* reliable means of contraception (systemic hormonal contraception, intrauterine contraceptive device, tubal ligation)
* using the same way of contraception during the previous 3 months
* normal clinical examination
* able to be compliant with the schedule of protocol assessments
* willing and able to provide written informed consent
* affiliated to a National Health Service
* agreeing to being registered on the national file for subjects participating in biomedical research
Exclusion Criteria:
* Exclusions related to significant medical disturbances :
* type I and II diabetes
* early menopause
* serious psychological disorders
* uncontrolled thyroid disorders
* know allergy to local anesthetics especially Xylocaine
* abnormal laboratory results
* medical history that, in the opinion of the investigator, makes the subject unsuitable for enrollment
* positive test result for HIV, HCV and/or HBV virus
* positive pregnancy test
* Exclusions related to subject lifestyle :
* smoking \> 10 cigarettes per day
* smoking cessation during the previous 3 months
* weight fluctuation (\>3kg) during the previous 3 months
* alcohol abuse
* coffee or tea consumption \> 6 cups per day
* high consumption of drinks comprising xanthine bases (\>0.5 liters/day)
* consumption of dr…
What they're measuring
1
To compare the number and the phenotype of cells between abdominal and gluteo-femoral adipose tissue in women.
Timeframe: There is no time frame. It's a comparison of adipose tissue composition between two locations, collected both at visit 2 (inclusion).