Tissue Engineered Nasal Cartilage for Regeneration of Articular Cartilage

Inclusion Criteria: * Size of the defect on the femoral cartilage:one or two symptomatic lesion(s) grade III-IV from 2 cm2 to 8 cm2 at the femoral condyle and/or trochlea * Other: * Age: 18-55 years * Written informed consent by the patient Exclusion Criteria: * Defect: * Lesions smaller than 2cm2 or greater than 8cm2 * Total area of all lesions bigger than 8cm2 * Lesions other than on the femoral condyle and/or trochlea * Any evidence of the following diseases in the target joint: septic arthritis; inflammatory joint disease; gout; recurrent episodes of pseudogout; Paget disease of bone; ochronosis; acromegaly; hemochromatosis;Wilson disease; primary osteochondromatosis; heritable disorders; collagen gene mutations * Presence of a clinically relevant cartilage lesion on the patella (second lesion) * Patellofemoral cartilage lesion * Presence of relevant complex knee injuries affecting bone and/or ligaments * Osteochondritis dissecans: recent (within 1 year before baseline); depth of lesion \>0.5 cm; subchondral sclerosis * Advanced osteoarthritis (as defined by Radiographic Atlas of Osteoarthritis, grade 2-3) * Varus or valgus malalignment exceeding 5° (kissing lesions out) * Medical history: * gravidity (Pregnancy) * breast feeding * presence of multiple severe allergies (including porcine collagen, streptomycin and penicillin) * Osteoarthritis * Current diagnosis of osteomyelitis * Any clinically significant or symptomatic vascular or n…