A Folinic Acid Intervention for Autism Spectrum Disorders

Inclusion Criteria * 1\. Autism Spectrum Disorder (as defined by a gold standard measure for ASD diagnosis: the Autism Diagnostic Observation Schedule and/or Autism Diagnostic Interview-Revised). In an event where sufficient diagnostic information is lacking, and the PI believes that the clients meet all other inclusion criteria and a prospective diagnosis of an ASD is clinically warranted, and a formal diagnosis is scheduled to occur within a reasonable time frame from the date of study entry but before dispersing study drug/placebo, then the client may be considered as potentially eligible. Furthermore, a research-reliable rater must complete the diagnosis. * 2\. 3 years to 14 years of age * 3\. Language Impairment * 4\. Ability to maintain complementary, traditional, and/or behavioral interventions and to attempt to keep them constant during the study, when possible. * 5\. Unchanged complementary, traditional, and/or behavioral intervention for approximately 8 weeks prior to study entry, when possible. Exclusion Criteria * 1\. Currently taking Antipsychotic medication * 2\. Vitamin or Element Supplementation that exceeds the IOM Tolerable Upper Intake Levels * 3\. Any moderate to severe positive response on that Aberrant Behavior Checklist Irritability subscale on questions: Injures self on purpose, is aggressive to other children or adults (verbally or physically), deliberately hurts himself/herself, and/or does physical violence to self. * 4\. Prematurity (\<34 weeks …