Genetics of Reproductive Disorders (Including Kallmann Syndrome) and Cleft Lip and/or Palate

Inclusion Criteria:(any of the following conditions) * hypogonadotropic hypogonadism * Kallmann syndrome * adult-onset hypogonadotropic hypogonadism * hypothalamic amenorrhea * polycystic ovarian syndrome * primary gonadal failure * precocious puberty * cleft lip/palate * family members of the above groups Exclusion Criteria: * acute illness/hospitalization * pituitary tumors * iron overload (hemochromatosis) * infiltrative diseases (sarcoidosis) * chronic alcohol abuse * illicit drug use * anabolic steroid abuse