CompletedPhase 3

Cyclosporine A in Cardiac Arrest

France796 participantsStarted 2010-06

Plain-language summary

The investigators hypothesised that cyclosporine A administration at the onset of cardiopulmonary resuscitation, by inhibiting the mitochondrial permeability transition pore, could prevent the post cardiac arrest syndrome and improve outcomes.

Who can participate

Age range18 Years – 80 Years

SexALL

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Inclusion Criteria: * Witnessed out-of-hospital cardiac arrest * Non shockable cardiac rhythm Exclusion Criteria: * Evidence of trauma * Evidence of pregnancy * Duration of no flow more than 30 minutes * Rapidly fatal underlying disease * Allergy to cyclosporin A

What they're measuring

Sequential Organ Failure Assessment score (SOFA)

Timeframe: At 24 hours after hospital admission

Trial details

NCT IDNCT01595958

SponsorHospices Civils de Lyon

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2013-03

View on ClinicalTrials.gov More Non Shockable Out of Hospital Cardiac Arrest trials