Cyclosporine A in Cardiac Arrest (NCT01595958) | Clinical Trial Compass
CompletedPhase 3
Cyclosporine A in Cardiac Arrest
France796 participantsStarted 2010-06
Plain-language summary
The investigators hypothesised that cyclosporine A administration at the onset of cardiopulmonary resuscitation, by inhibiting the mitochondrial permeability transition pore, could prevent the post cardiac arrest syndrome and improve outcomes.
Who can participate
Age range
18 Years – 80 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Witnessed out-of-hospital cardiac arrest
* Non shockable cardiac rhythm
Exclusion Criteria:
* Evidence of trauma
* Evidence of pregnancy
* Duration of no flow more than 30 minutes
* Rapidly fatal underlying disease
* Allergy to cyclosporin A
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1This trial studied Cyclosporine A specifically for non-shockable out-of-hospital cardiac arrest — does my situation match that specific type of cardiac arrest, and does that affect whether the findings are relevant to my care?
2The trial measured something called a SOFA score, which tracks how well organs like the kidneys, lungs, and heart are functioning after cardiac arrest — can you explain what my current organ function looks like and whether that kind of outcome measure matters for my treatment plan?
3Since this was a Phase 3 trial and its recruitment is now completed, are the results published and, if so, did Cyclosporine A actually show a meaningful benefit in reducing organ failure after cardiac arrest?
4Cyclosporine A is an immunosuppressant drug normally used to prevent organ rejection — are there particular risks or side effects I should know about when it's used in the setting of cardiac arrest recovery?
5Given that this trial is finished, is Cyclosporine A something doctors are now using in practice for cardiac arrest patients, or is standard post-resuscitation care still the recommended path for someone in my situation?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.