Successful Pregnancy and Delivery After AOA (NCT01595815) | Clinical Trial Compass
CompletedNot Applicable
Successful Pregnancy and Delivery After AOA
South Korea100 participantsStarted 2007-05
Plain-language summary
Artificial oocyte activation with strontium chloride or calcium ionophore improves fertilization, embryo quality, pregnancy and delivery rate in women who showed complete fertilization failure or low fertilization rates
Who can participate
Age range
20 Years – 45 Years
Sex
FEMALE
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Fertilization rate was less than 30% after conventional ICSI.
* Fertilization rate was less than 50% after ICSI with calcium ionophore.
* Repeated complete fertilization failure or low fertilization rates following ICSI in previous cycles
Exclusion Criteria:
* Fertilization rate was more than 30% after conventional ICSI
* Fertilization rate was more than 50% after ICSI with calcium ionophore.
* Successful pregnancy and delivery after ICSI in previous cycles
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1This trial studied a procedure called AOA — artificial oocyte activation — to help improve fertilization rates in cases of infertility. Could you explain whether AOA might be relevant to my specific situation, and what fertilization problems it was designed to address?
2Since this trial is listed as phase 'NA' and has already been completed, what do the results actually show about fertilization rates, and has AOA moved into standard clinical practice or is it still considered experimental?
3The trial focused on fertilization rate as its main measurement — but what I really care about is a healthy pregnancy and baby. Can you walk me through what the data shows beyond fertilization, such as pregnancy rates and birth outcomes, and how that should factor into my decision?
4Are there specific causes of infertility — like issues with the sperm's ability to activate the egg — where AOA would be more likely to help, and does my diagnosis suggest I might be a candidate worth discussing with a specialist?
5If AOA isn't the right path for me, what are the standard alternatives we should consider first, and how would you weigh those against a procedure that's still being studied like this one?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.