CompletedNot Applicable

Perioperative Opioid-induced Hyperalgesia and Its Prevention With Ketamine and Methadone

Italy113 participantsStarted 2009-12-01

Plain-language summary

Background: In perioperative period inhibition of N-Methyl-D-Aspartate receptor prevents opioid-induced hyperalgesia and reduce postoperative opioid requirement after abdominal surgery. Methadone is both a µ-opioid receptor agonist like Morphine and a N-Methyl-D-Aspartate antagonist. Study Aim. To evaluate the efficacy of intraoperative Ketamine and postoperative Methadone analgesia in preventing opioid-induced hyperalgesia after abdominal surgery.

Who can participate

Age range18 Years – 75 Years

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * patients undergoing open colo-rectal surgery Exclusion Criteria: * ASA status more than II, history of chronic pain, ischemic heart disease or chronic pulmonary disease, allergy to any drugs used in the protocol. Body Max Index more than 35.

What they're measuring

the Extent of Hyperalgesia Area Proximal to Surgical Wound

Timeframe: 24 and 48 hours after surgery

Trial details

NCT IDNCT01594047

SponsorFondazione IRCCS Istituto Nazionale dei Tumori, Milano

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2012-06-01

Results submitted2018-02-27

View on ClinicalTrials.gov More Post Operative Pain trials