Effectiveness of onaBoNT-A vs Oral Tamsulosin in Men With BPH and LUTS

Inclusion Criteria: * Males at least 50 years of age * American Urological Association Symptom Score greater than 8 * Voided volume greater than 125 ml * Maximum urinary flowrate less than 15 ml/sec. * Must agree to all procedures and willfully consented Exclusion Criteria: * Any prior surgical intervention or use of 5-alpha-reductase medical intervention for BPH * Current diagnosis of acute or chronic prostatitis (which may cause LUTS that mimic BPH) * Previous exposure to onabotulinumtoxinA * Overactive bladder without obstructive symptoms (i.e. decrease in force of stream, hesitancy, intermittency, post-void dribbling) * Active urinary tract disease or biopsy of the prostate within the past 6 weeks; * Two documented urinary tract infections of any type in the past year (UTI defined as greater than 100,000 colonies per ml urine from midstream clean catch or catheterized specimen) * Uncontrolled diabetes * History of bladder calculi (stones) * Penile prosthesis or artificial urinary sphincter \[placement\] * Documented bacterial or acute prostatitis within the past year * Episode of unstable angina pectoris, myocardial infarction, transient ischemic attack, or cerebrovascular accident (stroke) within the past 6 months * Known primary neurologic conditions such as multiple sclerosis, myasthenia gravis or Parkinson's disease, or other neurological diseases known to affect bladder function * History or current evidence of carcinoma of the prostate or bladder, pelvic radiatio…