A Study of ULTRAM ER at Two Dose Levels in Adolescents With Pain

Inclusion Criteria: * Confirmed need for control of pain due to injury or nonmalignant disease that does not influence fluid shifts and general drug disposition * Weighs at least 30 kg * Female participants must be premenarchal, surgically sterile, abstinent, or, if sexually active, be practicing an effective method of birth control * Able to swallow the intact tablet with the aid of water (participants may not chew, divide, dissolve, or crush the study drug) * Signed informed consent document indicating that he/she understands the purpose of and procedures required for the study and is willing to participate in the study * Informed consent signed by the parent(s) or the legal guardian(s) of the participant Exclusion Criteria: * History of or current clinically significant medical illness or condition including (but not limited to) cardiac disease, hematologic disease, coagulation disorders, lipid abnormalities, significant pulmonary disease, diabetes mellitus, renal or hepatic insufficiency, thyroid disease, neurologic or psychiatric disease, infection, or any other illness or condition that the investigator considers should exclude the participant or that could interfere with the interpretation of the study results