HemoControl System Activated in Hemodiafiltration Treatments

Inclusion Criteria: * A subject must meet ALL of the following inclusion criteria in order to participate in this study: * ESRD in chronic dialysis treatments for at least 3 months * Age ≥ 18 years * Body weight ≥ 40 kg * Blood flow rate ≥ 250 ml/min with a recirculation of the vascular access \< 5% * Use of not fractioned heparin in continuous infusion as anticoagulant * Stable anticoagulation dosage over the last 6 treatments * Stable dialysis prescription (Qb, Qd, treatment time) over the last 6 treatments * Informed consent for participating to the study * Stable Haemoglobin concentration at beginning of the treatment lower than or equal to 14 g/dl. Exclusion Criteria: * A subject shall NOT participate in the study if he/she meets ANY of the following criteria: * HIV positivity * Active Hepatitis A, B or C * Pregnancy * Participating in other clinical investigations during the course of this study * Failed to release consent * Known coagulation disorders (clotting problems) * Known bleeding risk * Clinical or laboratory diagnosis of acute infection * Recent (last 4 weeks) surgical intervention * Therapy prescribed is only HD, HF or isolated UF mode * Active phase cancer, * Active phase immune disease. * Serious hemostasis disorders.