High Cut Off Dialysis in Systemic Inflammatory Response Syndrome Patients After Cardiac Surgery

Inclusion Criteria: * Age ≥ 18 years * Scheduled for complex / prolonged cardiac surgery (i.e.combined CABG+ valve surgery, Redo surgery) with an anticipated CPB time \> 120 min * CKD with an e GFR \< 50ml/min/m2 * Euroscore \> 6 Exclusion Criteria: * End stage CKD (dialysis dependent) renal failure before surgery * Radiocontrast exposure within 24 hours before surgery * Active endocarditic with antibiotic treatment * pulmonary disease with chronic hypoxia * Clinically significant liver dysfunction (bilirubin \> 1.8mg/dl (30µmol/L)) * Known HIV, HCV infection * Alcoholism * Active uncontrolled infection * Pregnancy or lactation * Inability to give informed consent to participate in the study