CompletedNot Applicable

Developing and Treating a Mouse Model of Acute Myeloid Leukemia Using Tissue Samples From Younger Patients With Acute Myeloid Leukemia

United States10 participantsStarted 2012-05

Plain-language summary

These laboratory trial studies the development and treatment of a mouse model for acute myeloid leukemia (AML) using samples from younger patients with AML. Studying tissue samples from patients with cancer in the laboratory may help doctors learn more about cancer and how well patients will respond to treatment.

Who can participate

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Cryopreserved human AML samples * FLT3-ITD samples with high allelic ratios

What they're measuring

Engraftment ratio of human AML cells to murine cells

Timeframe: Up to 9 months

Efficacy of sorafenib or quizartinib to inhibit AML proliferation in vivo

Timeframe: Up to 9 months

Trial details

NCT IDNCT01576185

SponsorChildren's Oncology Group

Sponsor typeNETWORK

Study typeOBSERVATIONAL

Primary completion2016-05

View on ClinicalTrials.gov More Childhood Acute Myeloid Leukemia/Other Myeloid Malignancies trials