Clinical Diagnosis of Acute Porphyria

Group 1 Inclusion Criteria: * Be 15 years of age or older * Be a first-degree relative (child, sibling, parent, or grandparent) of an individual with genetically proven acute porphyria (AIP, HCP or VP) * Not have had any previous genetic testing for acute porphyria Group 2 Inclusion Criteria: * Be 15 years of age or older * Have a history of suggestive clinical features, such as abdominal, back or limb pain, recurrent nausea lasting days, reaction to medications, psychiatric history, or sun sensitivity. * An increase in urinary, fecal or serum porphobilinogen (PBG) and/or porphyrins Groups 1 and 2 Exclusion Criteria: * Have previously had genetic testing for acute porphyria * Have a history of "alarm" symptoms, such as anemia, unintentional weight loss, signs of GI (gastrointestinal) bleeding, or dysphagia (difficulty in swallowing). Follow Up Sub-Study (Group 3) Inclusion Criteria: * Have been seen by one of the Porphyria Consortium physicians/investigators 10 or more years prior to study initiation * Had a slight increase in porphyrins during the initial visit * Not given a diagnosis of porphyria at the time of the visit Follow Up Sub-Study (Group 3) Exclusion Criteria: * You have been seen by the Porphyria Consortium physician/investigator less than 10 years prior to study initiation.