Prasugrel for Prevention of Early Saphenous Vein Graft Thrombosis

Inclusion Criteria: * Age 18 years or greater * Willing and able to give informed consent. The patients must be able to comply with study procedures and follow-up. * Undergoing clinically-indicated coronary artery bypass graft surgery Exclusion Criteria: * Known allergy to aspirin or prasugrel * Need for concomitant cardiac procedure, such as valve repair or replacement * Increased risk of bleeding, including need for warfarin or dabigatran administration * Positive pregnancy test or breast-feeding * Coexisting conditions that limit life expectancy to less than 12 months or that could affect a patient's compliance with the protocol * Serum creatinine \> 2.5 mg/dL * Severe peripheral arterial disease limiting vascular access * Prior stroke or transient ischemic attack * Weight \<60 kg or age \>75 years * Multiple distal SVG anastomoses * Postoperative complications prolonging hospitalization