CompletedNot Applicable

Does Azithromycin Cause QT Prolongation in Hospitalized Patients With Severe Community Acquired Pneumonia?

Israel148 participantsStarted 2012-03

Plain-language summary

The macrolide group of antibiotics can cause QT prolongation, and endanger the patient with life threatening arrythmias. QT prolongation caused by Azythromycin, a relatively new macrolide, is extremely rare, and was not reported in clinical trials. Our hypothesis is that patients hospitalized with severe community acquired pneumonia, usually with multiple comorbid conditions will have a higher rate of QT prolongation, compared to the clinical trials published

Who can participate

Age range18 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Severe community acquired pneumonia * treated with azithromycin * age over 18 years Exclusion Criteria: * Azithromycin initiated before hospitalization * technically undecipherable ECG * Permanent pacemaker

What they're measuring

Corrected QT segment of ECG

Timeframe: Daily, at estimated peak antibiotic level, during index hospitalization

Trial details

NCT IDNCT01553734

SponsorHaEmek Medical Center, Israel

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2013-05

View on ClinicalTrials.gov More Pneumonia trials