CompletedNot Applicable

Studying Gene Expression in Samples From Younger Patients With Neuroblastoma

75 participantsStarted 2012-03

Plain-language summary

RATIONALE: Studying samples of blood and tumor tissue from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer. It may also help doctors find better ways to treat cancer. PURPOSE: This research trial studies gene expression in samples from younger patients with neuroblastoma.

Who can participate

Age range21 Years

SexALL

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DISEASE CHARACTERISTICS: * Tissue samples and matched plasma samples available from 1 of the following groups: * Patients with low-stage (International Neuroblastoma Staging System \[INSS\] stage 1 or 2) neuroblastoma (NBL) * Patients with advanced-stage (INSS stage 3 or 4) NBL * Patients with stage 4S NBL * Clinical and/or outcome data associated with the tissue and plasma samples including INSS stage, age, MYCN amplification status, chromosomal alterations, and 5-year survival, if known PATIENT CHARACTERISTICS: * Not specified PRIOR CONCURRENT THERAPY: * Not specified

What they're measuring

Expression of TβRIII in the neuroblastic tumor and stroma of patients with advanced-stage NBL

Correlation between TβRIII levels and TGF-β signaling correlate with NBL stage, tumor stroma content, surface TβRIII expression, and TGF-β signaling

Trial details

NCT IDNCT01553448

SponsorChildren's Oncology Group

Sponsor typeNETWORK

Study typeOBSERVATIONAL

Primary completion2016-05

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