CompletedPhase 3

Lowering the Risk of Operative Complications Using Atorvastatin Loading Dose

Brazil648 participantsStarted 2012-11

Plain-language summary

Patients submitted to noncardiac surgeries are at increased risk of serious cardiovascular complications. Statins have shown to lower cholesterol levels and reduce cardiovascular events in other scenarios. The objective of this study is to explore the effects of atorvastatin, as compared with placebo, on the 30-day risk of a composite of death, nonfatal Myocardial Injury after Noncardiac Surgery (MINS), or stroke among patients who undergo noncardiac surgery.

Who can participate

Age range40 Years

SexALL

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Inclusion criteria

✓. Major surgery;
✓. Emergency surgery;
✓. Previous history of heart failure;
✓. diabetes;
✓. Arterial hypertension;
✓. Smoking habit along the last two years;
✓. chronic kidney disease (creatinine greater than 2mg/dl);
✓. Patients older than 70 years.

What they're measuring

Composite outcome

Timeframe: 30 days

Trial details

NCT IDNCT01543555

SponsorHospital do Coracao

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2015-06

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