TPF Induction Chemotherapy for Locally Advanced and Resectable Oral Squamous Cell Carcinoma

Inclusion Criteria: * Written informed consent prior to any study activities * Age 18-75 years old * Histological biopsy confirming oral squamous cell carcinoma (tongue, gingiva, buccal mucosa, floor of mouth, palate, and retromolar region) * Clinical stage III/IVA (T1-2, N1-2, M0 or T3-4, N0-2, M0, UICC 2002), resectable lesions * Karnofsky performance status (KPS) \> 60 * Adequate hematologic function: white blood cell \> 3,000/mm\^3, hemoglobin \> 8g/L, platelet count \> 80,000/mm\^3 * Hepatic function: ALAT/ASAT \< 2.5 times the upper limit of normal (ULN), bilirubin \< 1.5 times ULN * Renal function: serum creatinine \< 1.5 x ULN * Life expectancy ≥ 6 months Exclusion Criteria: * Evidence of distant metastatic disease and other cancers * Surgical procedure of the primary tumor or lymph nodes (except diagnostic biopsy) before study treatment * Previous radiotherapy for the primary tumor or lymph nodes * Prior chemotherapy or immunotherapy for the primary tumor * Other previous malignancy within 5 years * Systematic diseases history of severe pulmonary or cardiac diseases * Creatinine Clearance \< 30 ml/min * Legal incapacity or limited legal capacity * Pregnancy (confirmed by serum or urine β-HCG) or lactation period