Transcatheter Aortic Valve Implantation Without Predilation

Inclusion Criteria: * LVEF ≤35% * Aortic valve stenosis with an aortic valve area \<1 cm2 (\<0,6 cm3/m2) * Males or females at least 18 years of age * Logistic EuroSCORE ≥15% and age ≥75 years or if age \<75 years: logistic EuroSCORE ≥20% and/or a significant contraindication for open heart surgery (e.g., porcelain aorta or severe COPD) * Signed informed consent Exclusion Criteria: * Patients with a device regulating the heart rhythm by pacing (e.g. pacemaker, resynchronization device, implanted defibrillator) * Patients with a pre-existing class I or class II indication for new pacemaker implantation according to the 2007 ESC guidelines * Lack of written informed consent, severe mental disorder, drug/alcohol addiction * Life expectancy \< 1 year * Hypersensitivity or contraindication to acetyl salicyl acid, heparin, ticlopidine, clopidogrel, nitinol or sensitivity to contrast media that cannot be adequately premedicated * Recent myocardial infarction (STEMI within the last 3 months) * Left ventricular or atrial thrombus by echocardiography * Uncontrolled atrial fibrillation * Mitral or tricuspidal valvular insufficiency (\> grade II) * Previous aortic valve replacement with mechanical valve * Evolutive or recent cerebrovascular event (within the last 3 months) * Vascular conditions that make insertion and endovascular access to the aortic valve impossible * Symptomatic carotid or vertebral arterial narrowing (\>70%) disease * Abdominal or thoracic aortic aneurysm in the p…