A Sleep Laboratory Study to Investigate the Safety and Efficacy of the Rotigotine Skin Patch in Subjects With Restless Legs Syndrome and End-Stage Renal Disease Requiring Hemodialysis

Inclusion Criteria: * End-Stage Renal Disease (ESRD) requiring hemodialysis and regular dialysis schedule * Fulfillment of pre-defined criteria of hematology parameters * Diagnosis of Restless Legs (RLS) based on the 4 cardinal diagnostic clinical features according to the International Restless Legs Syndrome Study Group * Initial response to previous dopaminergic treatment for RLS, or has had no previous dopaminergic treatment (ie, de novo) * Score of ≥ 15 points on the IRLS (indicating moderate to severe RLS) at Baseline * Score of ≥ 11 points on the RLS-DI (Diagnostic Index) at Baseline * Score of ≥ 4 points on the Clinical Global Impressions (CGI) Item 1 assessment (indicating moderately ill) at Baseline * Scores ≥ 15 Periodic Limb Movements (PLMs) per hour on the Periodic Limb Movement Index (PLMI) based on Polysomnography (PSG) (recorded during the second night) as assessed by the investigator at Baseline Exclusion Criteria: * Clinically relevant Polyneuropathy or Varicosis which cannot be clearly differentiated from RLS symptoms in the opinion of the investigator * Clinically relevant concomitant diseases, such as Attention Deficit Hyperactivity Disorder, Painful Legs, and Moving Toes * Other central nervous system diseases * Evidence of an impulse control disorder according to the modified Minnesota Impulsive Disorders Interview (mMIDI) * Lifetime history of suicide attempt (including an active attempt, interrupted attempt, or aborted attempt), or has suicidal idea…