A Study to Evaluate the Efficacy and Tolerance of WR279,396 for Old World Cutaneous Leishmaniasis

Inclusion Criteria: The study population will be selected from adults (18y) patients and children above 15y in Tunisia (Old World) * Age: 15 - 75 years old * Lesion character: each diameter (horizontal and vertical) of the lesion test must measure 7 mm, the lesion must be primarily ulcerative (i.e., not verrucous or nodular) and located in a biopsy friendly site of the body * Parasitological diagnosis: have cutaneous leishmaniasis proven parasitologically in lesion selected for inclusion in study (lesion test). * Informed consent: have given written informed consent to participate in the study: (i.e. patient or legal representative). Exclusion Criteria: * Drug intolerance: history of known or suspected hypersensitivity or idiosyncratic reactions to aminoglycosides in the patient or immediate family members. * Previous use of antileishmanial drugs (within 2 months) or present use of routinely nephrotoxic or ototoxic drugs. * Potential for follow up: Have less than 4 months time remaining in present address and/or plans to leave the area for more than 30 days. * Extent of disease: More than 10 lesions or lesion ³ 5 cm or a lesion less than 2 cm from eye, in the ear, or a lesion in the face, that in the opinion of the attending dermatologist could potentially cause significant disfigurement. * Location of disease: mucosal involvement. * Disseminated disease: clinically significant lymphadenitis with nodules that are painful and \> 1 cm in size in the lymphatic drainage of the…