The aim of this study is to determine whether supplementation of glutamine and fish oil can improve peripheral skeletal muscle function and metabolism in patients with heart failure. The investigators propose a randomized, double-blind, placebo controlled study comparing the combined supplementation of fish oil and glutamine with placebo in patients with stable heart failure. 30 patients with heart failure will be randomized to either receiving 6.5 g fish oil/d and 8 g glutamine/d (n=15) or placebo (n=15) for 90 days. The primary outcome in this study is the change in muscle functional capacity measured as changes in maximum muscle strength and fatigability, peak VO2 and exercise time after supplementation. A secondary outcome is the measurement of systemic and local markers of inflammation.
Age range
35 Years – 80 Years
Sex
ALL
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Baseline Skeletal Muscle Function Capacity- Isometric Contractions (PKTQ/BW)
Timeframe: Baseline
90 Day Skeletal Muscle Function Capacity- Isometric Contractions (PKTQ/BW)
Timeframe: 90 Days
Baseline Muscle Function Capacity- Isokinetic Contractions (PKTQ/BW)
Timeframe: Baseline
90 Day Muscle Function Capacity- Isokinetic Contractions (PKTQ/BW)
Timeframe: 90 Days
Baseline Muscle Function Capacity- Isokinetic Contractions (Work (WK)/Body Weight (BW))
Timeframe: Baseline
90 Days Muscle Function Capacity- Isokinetic Contractions (Work (WK)/Body Weight (BW))
Timeframe: 90 Days
Baseline Muscle Function Capacity- Isokinetic Contractions (Total Work)
Timeframe: Baseline
90 Day Muscle Function Capacity- Isokinetic Contractions (Total Work)
Timeframe: 90 Days
Baseline Muscle Function Capacity- Isokinetic Contractions (Average Power)
Timeframe: Baseline
90 Day Muscle Function Capacity- Isokinetic Contractions (Average Power)
Timeframe: 90 Days
Baseline Muscle Function Capacity- Isokinetic Contractions (Time to Peak Torque)
Timeframe: Baseline
90 Day Muscle Function Capacity- Isokinetic Contractions (Time to Peak Torque)
Timeframe: 90 Days
Percent Change in Peak Effort Oxygen Consumption
Timeframe: Baseline to 90 Days