Exploratory Study on the Mood and Cytokine Levels in Female Healthy Participants and Major Depressive Disorder Patients

Inclusion criteria: * Has body mass index (BMI) \[weight in kilograms / (height in meters x height in meters)\] between 18 and 30 kg/m2 * For young healthy participants: female, 25 to 45 years of age; elderly healthy participants: female: ≥ 65 years of age \& with baseline C-reactive protein (CRP) \> 5 mg/mL; (partially) remitted MDD patients: female, 25 to 45 years of age * Inclusion criteria specific for patients with MDD: -Patients with a history (within 24 months) of MDD must have a Montgomery-Asberg Depression Rating Scale (MADRS) total score \< 15 and symptom remission (temporary absence of disease symptoms) relative to the acute episode must have been present for at least 3 months Exclusion Criteria: * Has a current Diagnostic and Statistical Manual of Mental Disorders IV (DSM-IV) axis I diagnosis (other than MDD) * Has recently experienced a psychosocial stressor within 6 months * Has acute symptoms of suicidality (the likelihood of an individual completing suicide) * Has a DSM-IV diagnosis of substance abuse or dependence within 6 months prior to screening evaluation * Has been exposed to an experimental medication or experimental medical device within 90 days before screening * Has a serology (scientific study of blood serum and other bodily fluids) positive for hepatitis B surface antigen (HBsAg), hepatitis C antibodies or HIV antibodies at screening * Has been exposed to typhoid or typhoid vaccine within 5 years before screening * Has been prior exposed to the …