Effects of DPP-4 Inhibition on Triglycerides

Inclusion Criteria: * Willing to provide signed written informed consent * Men and women aged 18-80 years * Type 2 diabetes (as defined by the ADA - see reference 18) * Baseline HgbA1c between 6.5% and 8%; HgbA1c 7.5-8.0% among subjects taking sulfonylureas * Baseline plasma triglyceride concentration between 200 and 700 mg/dl * Stable diabetes medication regimen for at least 12 weeks prior to study entry * Taking a statin for at least 8 weeks, unless statin therapy is contraindicated or intolerable * Treatment with other lipid-lowering medications only if the dose has been stable for \> 8 weeks. * Non-smoker * Body mass index \< 45.0 kg/m2 * BP \< 140/85 * Normal serum TSH and free T4 concentrations (hypothyroid subjects taking a stable replacement dose of levothyroxine will be allowed if they are biochemically euthyroid) * Subjects will otherwise be healthy * Women of child-bearing potential must be willing to use reliable contraception, as defined by our IRB, throughout the study (There are currently no FDA recommended restrictions on the use of saxagliptin in sexually active men, or requirements for contraception in their wives or sexual partners) * Able and willing to complete study procedures Exclusion Criteria: * Transaminase concentrations \> 2 times the ULN. (Mild elevations of AST and ALT will be allowed up to 2x ULN at baseline if there is no evidence of viral hepatitis or intrinsic liver disease. Since many of these subjects may have some degree of hepatic stea…