Intratympanic Injection for Autoimmune Inner Ear Disease

Inclusion Criteria: * Diagnosis of autoimmune inner ear disease (AIED) by the principal investigator * Idiopathic, bilateral sensorineural hearing loss * History of, or audiograms showing, rapid progression of hearing loss * Bilateral loss of at least 30 dB in one or more frequencies (0.25 - 6 kHz) * Hearing responsive on high-dose oral steroids and steroid-dependent, as determined by history and the principal investigator. The subject can be taking oral steroid, at the maintenance level, if enrolled in the First Arm and, if enrolled in the Second Arm, will begin taper after the first injection. * Provided written informed consent for participation in the clinical study Exclusion Criteria: * Positive MRI for vestibular schwannoma * Positive FTA (syphilis) * Significant middle ear disease (e.g., otitis media) * Positive blood test for Lyme disease * Positive tuberculosis test * Concurrent or past treatment or use of medications and/or substances known to cause ototoxicity(for example, aminoglycosides \[e.g., gentamicin\], cisplatin, loop diuretics, Yorgason et al., 2006) * Known adverse reaction to golimumab, adalimumab, etanercept, infliximab, rituximab, ustekinumab, or other biologic immunomodulators * Concurrent (within the past 3 months prior to enrollment) live viral intranasal vaccine (flu) * Positive test for HIV * Positive test for Hepatitis B and C * Presence of a demyelinating disease, such as multiple sclerosis * Women of childbearing potential only: Positive ser…