CompletedNot Applicable

Blood Vessel Study

United States178 participantsStarted 2012-03-01

Plain-language summary

Background: \- The endothelium is the inner lining of blood vessels. The cells in this lining help regulate blood flow and immune system function. Problems with endothelial cells can contribute to heart disease, high blood pressure, and diabetes. Certain genes or parts of genes may be related to problems with endothelial function. Researchers want to study healthy adults who have genes that may affect their endothelial function. More information on these genes may provide more information on genetic risk for certain diseases. Objectives: \- To study healthy adults who have genetic markers related to endothelial cell problems. Eligibility: * Healthy volunteers between 18 and 65 years of age. * Current participants of the Environmental Polymorphisms Registry and have certain genes related to endothelial cell problems. Design: * Participants will have a single study visit to collect information and samples. * Participants will be screened with a physical exam and medical history. Blood and urine samples will be collected. * Participants will have an ultrasound of the artery in the arm and will be given a short-acting medication called nitroglycerin to study blood flow and blood pressure.

Who can participate

Age range18 Years – 65 Years

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

* INCLUSION CRITERIA: * Participant of the Environmental Polymorphisms Registry and current contact information available * Genotype information available for relevant CYP2J2 and EPHX2 polymorphisms, which indicates: * WT for EPHX2 K55R and WT for CYP2J2 7 * WT for EPHX2 K55R and heterozygous for CYP2J2 7 * WT for EPHX2 K55R and homozygous for CYP2J2 7 * WT for CYP2J2 7 and heterozygous for EPHX2 K55R (N=30) * WT for CYP2J2 7 and homozygous for EPHX2 K55R (N=30) * Age 18-70 years * Willing and able to provide informed consent * Able to comply with all protocol procedures EXCLUSION CRITERIA: * Currently pregnant or breast feeding * Hospitalized for a cardiovascular disease or stroke event within the previous 3 months * Current use of long-acting nitrates (e.g., isosorbide mononitrate, isosorbide dinitrate) * Current use of medications taken for hypertension. * For participants with current daily or chronic use of NSAIDs; unable or unwilling to refrain from taking NSAIDs for 7 days prior to enrollment visit. * Current use of insulin for Type I Diabetes * Presence of a pacemaker or implanted cardioverter-defibrillator * Presence of an irregular heart rhythm (atrial fibrillation) at the study visit * Current resting heart rate \<40 or \>125 beats per minute * Current systolic blood pressure \<90 or \>180 mmHg, or diastolic blood pressure \>110 mmHg * Skin sensitivity precluding use of ECG electrodes * History of hypersensitivity to nitroglycerin or other nitrates or …

What they're measuring

-Change in digital pulsatile pressure-Endothelium-independent vasodilation-Change in brachial artery blood flow velocity -Serum levels of inflammatory markers -Serum and urine levels of cytochrome P450 epoxygenase pathway biomarkers@...

Timeframe: analysis

Trial details

NCT IDNCT01524549

SponsorNational Institute of Environmental Health Sciences (NIEHS)

Sponsor typeNIH

Study typeOBSERVATIONAL