Comparison of Metoclopramide and Ibuprofen for the Treatment of Acute Mountain Sickness

Inclusion Criteria: * Presence at Manang recruitment center (at approximately 11,500 ft) during the dates March through May, 2012. * Recent increase in altitude of \> 1000 ft vertical in last 24 hours * Presence of headache and at least one other symptom required for diagnosis of acute mountain sickness (including nausea, vomiting, fatigue, weakness, dizziness, lightheadedness or poor sleeping.) Exclusion Criteria: * Age less than 19 years old * Known allergy or contraindication to either ibuprofen or metoclopramide * Evidence of severe high altitude illness (e.g. High altitude pulmonary edema (HAPE) as evidenced by dyspnea at rest -- or of High Altitude Cerebral Edema (HACE) as evidenced by altered mental status or ataxia) * Known or suspected pregnancy * Use of other analgesic or antiemetic within 8 hours of study enrollment * History of migraines or other chronic headache disorders * Inability to provide informed consent