CompletedNot Applicable

The Effect of Music Periodicity on Interictal Epileptiform Discharges

United States10 participantsStarted 2004-02

Plain-language summary

The purpose of this study is to determine if having children listen to the music of Wolfgang Amadeus Mozart (Sonata for Two Pianos in D Major, K. 448) will lessen the amount of spike discharges on his/her Electroencephalography (EEG). These spike discharges often occur during a 24 hour period in the EEG of a child with Benign Childhood Epilepsy with Centrotemporal Spikes (BCECTS), or Rolandic Epilepsy. Should there be a decrease in the amount of spike discharges after listening to Mozart's music, this information may lead to new understanding and possible treatments for epilepsy.

Who can participate

Age range5 Years – 12 Years

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Female or male with BCECTS clinical history, and at least one seizure, as defined by the International League Against Epilepsy. * EEG consistent with features of BCECTS: centrotemporal (rolandic) interictal spike discharges (ISDs) with otherwise normal background interictal EEG * Screening neurological examination normal (by PI or other pediatric neurologist in the Division of Pediatric Neurology at MUSC) * Age 5-12 years, inclusive * On less than or equal to 2 anti-epileptic drugs (AED) \[Range 0-2 AEDs\] Exclusion Criteria: * Currently taking Clonazepam or other Benzodiazepines * Inability to complete 12 hour admission and comply with study protocol * Prohibited Therapy or Activities During Study Period: Use of computer or video games. Viewing of video tapes will be prohibited due to potential effect of music in videos on underlying process of study. * Due to the confounding factor of probably suppression of IEDs after a clinical seizure, any subject experiencing a seizure of any duration 24 hours prior to beginning the study will be excluded from the study. * For any subject experiencing a seizure during the study, data analysis will cease from that point onward.

Trial details

NCT IDNCT01515436

SponsorMedical University of South Carolina

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2004-05