CompletedNot Applicable

Studying Biomarker Expression in Samples From Patients With Down Syndrome and Acute Myeloid Leukemia or Other Transient Myeloproliferative Disorder

60 participantsStarted 2012-02

Plain-language summary

RATIONALE: Studying samples of blood, tissue, and bone marrow from patients with cancer in the laboratory may help doctors learn about changes that occur in RNA and identify biomarkers related to cancer. PURPOSE: This research trial studies RNA samples from patients with Down syndrome and acute myeloid leukemia or other transient myeloproliferative disorder.

Who can participate

Age range3 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

DISEASE CHARACTERISTICS: * Patients with Down syndrome (DS) diagnosed with acute myeloid leukemia or transient myeloproliferative disorder * Clinical samples obtained from patients enrolled on the COG AAML0431 and COG AAML08B1 PATIENT CHARACTERISTICS: * Previously consented to biologic studies PRIOR CONCURRENT THERAPY: * See Disease Characteristics

What they're measuring

Gene expression levels between DS AMKL and non-DS AMKL patients

Trial details

NCT IDNCT01511575

SponsorChildren's Oncology Group

Sponsor typeNETWORK

Study typeOBSERVATIONAL

Primary completion2016-05

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