CompletedNot Applicable

Iron Repletion in Chronic Cough and Iron Deficiency

Italy22 participantsStarted 2002-01

Plain-language summary

Chronic cough is more frequent and severe in women than in men. Women often have decreased iron stores, due to menses and pregnancies. Aim of the study: to investigate if iron deficiency has a role in chronic cough by favouring airway hypersensitivity to inhaled irritants.

Who can participate

Age range15 Years – 70 Years

SexFEMALE

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Unexplained cough : no detectable trigger for chronic cough identified, such as persistent rhinitis, chronic sinusitis, gastroesophageal reflux disease and asthma. * no benefit by prior treatment with antiH1-histaminic drug and proton pump inhibitor. * iron deficiency. * normal lung function tests and chest radiography no relevant systemic disease. * no acute respiratory infection in the last eight weeks. * no pharmacological treatment in the last two weeks. Exclusion Criteria:

What they're measuring

Change in cough VAS

Timeframe: after 2 months empiric treatment and 2 months iron supplementation

Change in laryngeal histamine threshold

Timeframe: after 2 months empiric treatment and 2 months iron supplementation

Change in cough histamine threshold

Timeframe: after 2 months empiric treatment and 2 months iron supplementation

Trial details

NCT IDNCT01507792

SponsorUniversity of Turin, Italy

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2011-01

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