CompletedNot Applicable

Iron Repletion in Chronic Cough and Iron Deficiency

Italy22 participantsStarted 2002-01

Plain-language summary

Chronic cough is more frequent and severe in women than in men. Women often have decreased iron stores, due to menses and pregnancies. Aim of the study: to investigate if iron deficiency has a role in chronic cough by favouring airway hypersensitivity to inhaled irritants.

Who can participate

Age range

15 Years – 70 Years

Sex

FEMALE

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Unexplained cough : no detectable trigger for chronic cough identified, such as persistent rhinitis, chronic sinusitis, gastroesophageal reflux disease and asthma. * no benefit by prior treatment with antiH1-histaminic drug and proton pump inhibitor. * iron deficiency. * normal lung function tests and chest radiography no relevant systemic disease. * no acute respiratory infection in the last eight weeks. * no pharmacological treatment in the last two weeks. Exclusion Criteria:

Questions worth asking your doctor

Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.

1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?

Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.

Questions for the trial coordinator

The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.

1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?

A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.

What they're measuring

Change in cough VAS

Timeframe: after 2 months empiric treatment and 2 months iron supplementation

Change in laryngeal histamine threshold

Timeframe: after 2 months empiric treatment and 2 months iron supplementation

Change in cough histamine threshold

Timeframe: after 2 months empiric treatment and 2 months iron supplementation

Trial details

NCT IDNCT01507792

SponsorUniversity of Turin, Italy

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2011-01

View on ClinicalTrials.gov More Cough trials

Who can participate

Age range

15 Years – 70 Years

Sex

FEMALE

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

What they're measuring

Change in cough VAS

Timeframe: after 2 months empiric treatment and 2 months iron supplementation

Change in laryngeal histamine threshold

Timeframe: after 2 months empiric treatment and 2 months iron supplementation

Change in cough histamine threshold

Timeframe: after 2 months empiric treatment and 2 months iron supplementation