Efficacy and Safety Study of Avastin to Treat Neovascularisation of the Cornea (NCT01501760) | Clinical Trial Compass
CompletedPhase 3
Efficacy and Safety Study of Avastin to Treat Neovascularisation of the Cornea
France38 participantsStarted 2012-05-13
Plain-language summary
Corneal newvessels may arise from a fan of pathologies, inducing long-standing corneal opacification requiring keratoplasty. These last years, VEGF inhibitors have been designed to reduce newascularization induced by gastric cancer or age-related macular degeneration. A few reports have been published showing the interest of VEGF inhibitors to treat corneal newvessels, but no randomized study has been achieved to date.
This study is designed to assess the efficacy of Bevacizumab, a VEGF inhibitor monoclonal antibody, to reduce the surface of corneal newvessels in when compared to placebo
Who can participate
Age range
18 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
inclusion criteria:
* Patients with corneal neovascularization whatever the origin
* Patient did not receive treatment with topical corticosteroids during the month preceding inclusion.
* Patient who has been properly informed and signed consent
* Patient aged over 18
* Patient affiliated with a health insurance plan or benefit of such a regime
Exclusion Criteria:
* Patients who received local or general treatment of concomitant prostaglandin derivatives
* Patients with current infection of the cornea or other tissue / organ
* Women of childbearing age without contraception
* Pregnancy and Lactation
* Patient participating in another study
* Patient with contact lenses
* Patients with uncontrolled hypertension
* Patient with a history of stroke, myocardial infarction, angina pectoris, thrombophlebitis, Raynaud's phenomenon.
* Patients hypersensitive to the active substance or any excipients
* Patients hypersensitive to products of Chinese hamster ovary cells or other recombinant human or humanized antibodies.
* Patients with active bacterial eye infections, fungal, parasitic or viral infection (with the exception of herpes)
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.